multigene panel tests
Genetic tests that use next-generation sequencing to test multiple genes simultaneously. Also called multigene test and multiple-gene test.
Extra information
‘A multigene panel that includes PRKAR1A and other genes of interest may be considered. Note: (1) Thee genes included in the panel and the diagnostic sensitivity of the testing used for each gene vary by laboratory and are likely to change over time. (2) Some multigene panels may include genes not associated with the condition discussed in this GeneReview; thus, clinicians need to determine which multigene panel is most likely to identify the genetic cause of the condition at the most reasonable cost while limiting identifcation of variants of uncertain significance and pathogenic variants in genes that do not explain the underlying phenotype. (3) In some laboratories, panel options may include a custom laboratory-designed panel and/or custom phenotype-focused exome analysis that includes genes specified by the clinician. (4) Methods used in a panel may include sequence analysis, deletion/duplication analysis, and/or other non-sequencing-based tests. For this disorder a multigene panel that also includes deletion/duplication analysis is recommended.
((https://www.ncbi.nlm.nih.gov/books/NBK1286/pdf/Bookshelf_NBK1286.pdf))
2021-04-18